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Final score Mitch Wishnowsky San Francisco 49ers Jersey , recap, injury report for 49ers-Chargers 49ers-Chargers final scoreThe 49ers impressed in their first start after losing Jimmy Garoppolo. They still struggle with tackles, but C.J. Beathard was quite impressive in his 2018 debut. The 49ers lost 29-27, but Beathard impressed with 298 passing yards and two touchdowns. He threw two interceptions, but one was a drop by George Kittle, and one came after Beathard was bum-rushed late in the game. He took some big hits and generally played solid football in the loss.49ers driving heading into 4th quarterIt’s hard to keep up with what has been an exciting game. The 49ers trailed 26-17, but C.J. Beathard connected with George Kittle for an 85-yard touchdown on a catch and run. The 49ers forced the Chargers to punt and now the 49ers have the ball at midfield, trailing 26-24 heading into the fourth quarter.Injury updatesThe 49ers return in the third quarter with Joe Staley and Dante Pettis both ruled out. Erik Magnuson is in at right tackle for Mike McGlinchey who left earlier with some kind of lower leg issue. The game is tied up 17-17 heading into the third quarter.Joe Staley injures kneeThe 49ers lead the Chargers 17-6, but have suffered a tough loss on the offensive line. Left tackle Joe Staley suffered a knee injury midway through the second quarter when Derwin James got a big hit on C.J. Beathard. Staley walked off the field and has since walked back to the locker room. He is listed as questionable to return.49ers take 14-0 lead!The 49ers are rolling early. C.J. Beathard found Kendrick Bourne on a short slant route for the score.49ers take 7-0 lead on pick-sixThe 49ers did not waste any time getting on the board to take a lead on the Chargers. On the third play of the game, Philip Rivers threw a pass intercepted by safety Antone Exum. Exum ran the ball back 31 yards for the score. Exum is playing in place of an injured Jaquiski Tartt.Dante Pettis knee injuryThe 49ers rookie injured his knee on a punt return in the first quarter, and is questionable to return. He was down and in pain, and needed help walking off the field. He went to the blue injury tent, and was then carted to the locker room.Week 4 inactivesThe 49ers and Chargers announced their inactives, and good news for the most part for San Francisco. Both running backs, Matt Breida and Alfred Morris, will play. Additionally, Antone Exum, who was downgraded to questionable on Saturday due to a quadricep injury, is active and will start at strong safety. Richard Sherman was ruled out on Friday, while Jaquiski Tartt had been listed as doubtful.49ers inactives: WR Richie James, CB Richard Sherman, S Jaquiski Tartt, OG Joshua Garnett, OL Najee Toran, DL Jullian Taylor, OT Shon ColemanChargers inactives: LB Kyzir White, C Cole Toner, T Joe Barksdale, G Forrest Lamp, WR JJ Jones, DT T.Y. McGill, DE Joey BosaAdrian Colbert injury updateSafety Adrian Colbert was listed as questionable for Week 4 with a hip injury he suffered last week. He was a DNP on Wednesday, and limited Thursday and Friday. Based on pre-game workouts, it would appear he is set to be active for the game.Matt Breida, Alfred Morris injury updatesThe 49ers are expected to have both of their starting running backs for Week 4, according to Ian Rapoport and Adam Schefter. Breida suffered a knee injury last Sunday and was limited on Wednesday and Friday. Morris suffered a knee injury during the practice week, and was limited on Thursday and Friday. Breida leads the NFL in yards per carry, and he and Morris need to get yards against the Chargers to set up C.J. Beathard for success.49ers-Chargers previewThe San Francisco 49ers are back on the road for the second time in a row. This time the milage isn’t as bad as they head to Los Angeles to take on the Chargers. While the short travel is nice, the 49ers have lost Jimmy Garoppolo for the season, making C.J. Beathard the starting quarterback going forward. This will be the first time to see if Beathard has improved on his rookie season, and with a second year in Kyle Shanahan’s offense, we can all cross our fingers.This will be an afternoon game kicking off at 1:25 PM.The game will air on CBS and you can see who gets it by looking at our broadcast map. Andrew Catalon and James Lofton will be in the booth. The 49ers were mounting a comeback against the Kansas City Chiefs in Week 3, but no sooner did they make a redzone trip to make things interesting, Jimmy Garoppolo made an ill-advised cut and blew out his ACL, putting him out for the season. The team now will lean on C.J. Beathard to get through 2018. Beathard finished 2017 winning only one game and completing 54.9 percent of his passes. He finished his stint as a starter with four touchdown passes to six interceptions. The offense can continue to develop in Garoppolo’s absence, but if Beathard will hold them back with his own play is something to watch. For Week 4, the Chargers will be without defensive lineman Joey Bosa. Wide receivers Keenan Allen (Knee) is questionable while wide receiver Travis Benjamin (foot) is a game-time decision. Right tackle Joe Barksdale will also be out after injuring his knee in Week 1The 49ers are fighting numerous injuries. Matt Breida (knee) remains a gametime decision. Cornerback Richard Sherman (calf) will be missing the game.Safety Jaquiski Tartt (shoulder) also is doubtful.Nuts and boltsLocation: Stubhub Center, Los Angeles, CAGame time: Sunday, September 30th, 1:25 P.M. PTTV channel: CBSOnline streaming: NFL Game PassLocal Radio: 810-AM, 107.7 (Ted Robinson, Tim Ryan) | Full listingsSports USA national radio: Bob Fitzgerald, Hank BauerSpanish Radio: KTRB 860-AM (Jes煤s Z谩rate, Gabriel Sotelo)Matchup history: Series tied at 7-7Announcers: Andrew Catalon, James LoftonEnemy blog: Bolts from the BlueTwitter: @ninersnationFacebook: Go ahead and give us a like!Instagram: @ninersnationsbnRegular season scheduleWeek 1: @ Minnesota Vikings — 24-16 LossWeek 2: vs. Detroit Lions, — 30-27 WinWeek 3: @ Kansas City Chiefs, 10:00 a.m., FOX, Sunday, September 23 — 38-27 LossWeek 4: @ Los Angeles Chargers, 1:25 p.m., CBS, Sunday, September 30Week 5: vs. Arizona Cardinals, 1:25 p.m., FOX, Sunday, October 7Week 6: @ Green Bay Packers, 5:15 p.m., ESPN, Monday, October 15Week 7: vs. Los Angeles Rams, 5:20 p.m., NBC, Sunday, October 21Week 8: @ Arizona Cardinals, 1:25 p.m., FOX, Sunday, October 28Week 9: vs. Oakland Raiders, 5:20 p.m., NFL Network, Thursday Fred Warner Jersey , November 1Week 10: vs. New York Giants, 5:15 p.m., ESPN, Monday, November 12Week 11: BYEWeek 12: @ Tampa Bay Buccaneers, 10:00 a.m., FOX, Sunday, November 25Week 13: @ Seattle Seahawks, 5:20 p.m., NBC, Sunday, December 2Week 14: vs. Denver Broncos, 1:05 p.m., CBS, Sunday, December 9Week 15: vs. Seattle Seahawks, 1:05 p.m., FOX, Sunday, December 16Week 16: vs. Chicago Bears, 1:05 p.m., FOX, Sunday, December 23Week 17: @ Los Angeles Rams, 1:25 p.m., FOX, Sunday, December 30Previewing Patrick Mahomes, Tyreek Hill and the Chiefs’ potent offense The 49ers will be limping into Arrowhead Stadium on Sunday, after narrowly escaping the clutches of defeat against the Lions. What awaits them? Oh, just the NFL’s hottest offense, featuring the likes of quarterback Patrick Mahomes, wideout Tyreek Hill, and tight end Travis Kelce. On top of all of that, they have one of the most creative play callers, Andy Reid, to push all the right buttons. Through the first two weeks of the season, the Chiefs are the highest scoring offense at 40 points per game. Their signal caller leads the league in passing touchdowns, with 10. Their No. 1 receiver is third in the NFL with 259 receiving yards. Per Pro Football Focus, the Chiefs’ offense has at least four players with a grade of 86.0 — Mahomes, Kelce, Hill and newly-acquired wideout Sammy Watkins.Kansas City continues to have balance in their offense, running 59 pass plays to 52 run plays. But their passing offense been wildly effective, averaging 10.4 yards per attempt, which is second in the NFL to Tampa Bay’s 13.4 Y/A. 49ers’ defensive coordinator Robert Saleh will have his hands full this week trying to create a scheme to slow down this Chiefs’ offense. Let’s take a look at some highlights of Mahomes, Hill and Kansas City’s passing offense to give 49ers’ fans an idea of what’s coming on Sunday.First up, here’s a play early in the Chiefs’ opener against the Chargers. It’s a simple slant route from Hill, who makes the catch on the run and takes it to the house for 58 yards. Hill was able to successfully find the open spot in the zone and the Chargers’ safety takes a bad angle to the tackle, allowing the Chiefs’ wideout to sneak by. Poor angles from defenders and Hill will throw up the peace sign on the way to the end zone.Here’s a play that Reid loves to run with the Chiefs. When they motion either Hill or wide receiver De’Anthony Thomas and leave the edge defender unblocked, it likely means that this toss play is coming. In this instance, Hill is able to take it for 21 yards. The 49ers’ edge defenders will have to make the tackle, otherwise it’ll turn into a huge gain. This clip below shows Mahomes’ arm strength, as he throws an absolute laser — (reminded me of Colin Kaepernick, actually) — to Watkins for a 16-yard gain. The throw wasn’t on target, but Watkins is able to lay out and make the diving catch to set up the Chiefs for a first and goal. Aaron Rodgers or Patrick Mahomes? I mean Mahomes is scrambling to the right and throws an absolute dart to Hill for 34 yards on a third-down play. If the 49ers’ pass rush allows Mahomes to leak out of the pocket, he still has the ability to make devastating plays with his arm.Now on the flip side, Mahomes shows off his touch on the deep throw here. The Chiefs’ fullback Anthony Sherman comes out of the backfield, easily beating the Chargers’ linebacker down the sideline. Mahomes drops in the throw perfectly over the linebacker’s head, allowing Sherman to score easily.Now against Pittsburgh, the Chiefs’ offense was highly efficient. They scored 42 points on 54 plays, scored touchdowns on all four red-zone trips and completed 82 percent of their passing attempts. Mahomes is definitely no rookie on the field, he’s able to dissect the Steelers’ defense here, finding the breakdown and beating them for a 15-yard touchdown to wideout Chris Conley.Kelce was awfully quiet in Week 1, for his standards, but joined the passing party in Pittsburgh. This throw from Mahomes was behind the tight end, but Kelce is able to turn around and make the 19-yard catch in between defenders for his first touchdown.Here’s an example of something the 49ers’ cornerbacks can’t do against Hill. Steelers’ corner Artie Burns doesn’t jam Hill at the line of scrimmage, allowing a free release and gets burned for 36 yards. 49ers’ corner Ahkello Witherspoon — who’s likely getting the Hill assignment — will either need to play off of the speedster or press him at the line, otherwise it could be six points on the scoreboard for the Chiefs.Another bread and butter play for the Chiefs is to use the middle of the field for their super star tight end. 49ers’ safety Jaquiski Tartt, along with linebackers Fred Warner and Reuben Foster, will likely get the challenge of guarding Kelce on Sunday. The Chiefs get 31 easy yards on this pitch and catch to Kelce right up the middle of the field. Last, Mahomes is solid in the face of pressure. Last Sunday in Pittsburgh, Mahomes completed eight of 12 passes for 126 yards and two touchdowns against the blitz, per Pro Football Focus. The 49ers are going to have to be careful bringing extra rushers, because they are going to be exposed in the back end against the Chiefs’ weapons. Steelers’ T.J. Watt blitzes Mahomes and the Chiefs’ quarterback throws right into the blitz, making it look extremely trivial. It turns into an easy 11-yard gain to Hill. Simply put, the Chiefs’ potent offense should be lethal on Sunday, if they don’t self destruct. I think the 49ers’ defense is going to struggle stopping the array of weapons that Mahomes has at his disposal from Hill to Kelce to Watkins to running back Kareem Hunt. The addition of Foster will be key, allowing him and Warner to man the middle of the field. Corner Ahkello Witherspoon will need to bounce back after last week’s clunker and veteran Richard Sherman will need to be solid. The 49ers’ pass rush outside of lineman DeForest Buckner has been inconsistent, but they’ll need to generate pressure by only rushing four on Sunday. If I had to guess, I’d predict that this matchup ends up being a track meet between the two offenses, similar to the Chiefs-Steelers game last week. If the 49ers’ offense isn’t able to score at a high clip, this could end up getting ugly.